Minimum inhibitory concentration values were compared with control and zone of inhibition values were compared. Aug 11, 2009 the present study describes the phytochemical profile and antimicrobial activity of andrographis paniculata. The antimicrobial activity was determined by disc diffusion method. Antimalarial activity of andrographis paniculata kalmegh against plasmodium berghei nk 65 in mastomys natalensis. So, in this study we evaluate the antibacterial, antifungal and antioxidant. In china, india, thailand, and malaysia, this plant has been widely used for treating sore throat, flu, and upper respiratory tract infections. Controlled clinical studies have indicated that andrographis paniculata is effective at reducing the prevalence and intensity of colds and sinusitis, and shortening the duration of the symptoms. The present investigation is part of continuing programme related to the phytochemical screening of andrographis paniculata nees kalmegh and effect of antibiotics mixing with the andrographis paniculata nees herbal extracts their enhanced. Benchalokawichian, a thai herbal remedy, is one of the medicines listed in the thailand national list of essential medicines that is typically used for relief of fever 7. Moreover, administration of a single oral dose of powder, up to 6 g, to healthy volunteers in a randomized crossover manner or daily administration of 0.
The antimicrobial activity of aqueous extract of andrographis paniculata or andrographolides and arabinogalactan proteins from a. Antibacterial activity of andrographis paniculata nees. Andrographis paniculata was considered to be a rich depository of bioactive compounds with antibacterial, antifungal, antiviral, antifouling, antibiofilm, immunosuppressant and cytotoxic activities. Modern research has investigated it for activity against various bacteria, viruses, and parasites. Aim the aim is to test the antimicrobial activity of andrographis paniculata, azadirachta indica neem, and curcuma longa curcumin as a root canal irrigant, against staphylococcus aureus and. Antifungal activity of andrographis paniculata extracts and active principles against skin pathogenic fungal strains in vitro abubakar sule1, qamar uddin ahmed2, jalifah latip3, othman abd. Andrographis paniculata, known as the king of bitters, is traditionally used in ayurveda and chinese medicine.
Infectious diseases are one of the significant causes of mortality and morbidity in developing countries. Antimicrobial activity of andrographis paniculata stem. The increasing of antibiotic resistance bacteria and synthetic drugs has urged the search of new antibacterial and antioxidant agents from medicinal plants. In the present study the methanolic leaf extract of andrographis paniculata has showed its anti quorum sensing activity against. Andrographis paniculata grows erect to a height of 30 110 cm in moist, shady places. Journal of the medical association of thailand, 1990, 73.
Andrographolide, a major bioactive chemical constituent of the plant, has shown anticancer potential in various. These have activity in different mechanisms including antibacterial, antioxidant, andor antiinflammation effects 6. Prajapati nd, purohit ss, sharma ak, kumar ta 2003. Antimicrobial activity of the chloroform extracts of the root and the stem andrographis paniculata nees. Prophylactic effect of andrographis paniculata extracts. Phytochemical analysis of andrographis paniculata extract. Antimicrobial activity of leaf extract of andrographis paniculata wall. Antimicrobial properties of various extracts of andrographis neesiana wight an endemic.
The objective of this study is to formulate and evaluate the effect of shea butter unrefined and refined on the antimicrobial activity of andrographis paniculata cream and also to investigate the physical stability of the cream. Journal of international immunopharmacology, 7, 515523. The antimicrobial properties of andrographis paniculata leaves have been studied by various researchers. The compounds which lead to antimicrobial activity need to be evaluated. A potent antibacterial plant 347 25 mgml crude powder. Handbook of medicinal plants, a complete source book, agrobios.
Minimum inhibitory concentration values were compared with control and zone of inhibition values were compared with standard ciprofloxacin in concentration 100 and 200. The antimicrobial activity of methanol, ethanol, acetone, chloroform and petroleum ether extracts of stem showed in table 2. The leaves were analyzed using gas chromatographymass. The aqueous extract showed significant antimicrobial activity, which may be due to the combined effect of the isolated arabinogalactan proteins and andrographolides. Andrographis paniculata, antimicrobial activity, pathogens, chloroform, methanol 1.
Hepatoprotective and antioxidant property of andrographis. Generally, andrographolide was extracted from leaves and aerial parts of a. The focal intent of the study is about quorum sensing qs which is well known for biofilm production, bacterial virulence and antibiotic resistance. However the medicinal values of their endophytes have not been investigated. Antimicrobial activity of leaf extract of andrographis. Recently, various biological activities of ap extract or andrographolide and, such as immunostimulatory activity, antiinflammatory effect, cytokine induction or deduction, a potential cancer therapeutic agent and t cell activation suppression. Minimum inhibitory concentration values were compared with control and zone of inhibition.
The aerial part of the plant was screened for their phytochemical properties and antimicrobial activity. Phytochemical extraction and characterization of the. Aim the aim is to test the antimicrobial activity of andrographis paniculata, azadirachta indica neem, and curcuma longa curcumin as a root canal. A comparative study on the effect of leaf extract of andrographis paniculata has been conducted 26,27. In vitro evaluation of antibacterial activity of chloroform. An aqueous and two ethanolic extracts of andrographis paniculata, used in traditional chinese, thai and indian medicine and andrographolide, an active principle of andrographis paniculata, were investigated for their antimicrobial activity against nine bacterial species including salmonella typhimurium, escherichia coli, shigella sonnei, staphylococcus aureus, pseudomonas aeruginosa. F nees, generally known as king of bitters, is an herbaceous plant in the family acanthaceae. Study of antioxidant and antimicrobial activities of.
Minimum inhibitory concentration values were compared with control and zone of inhibition values were compared with standard ciprofloxacin. The antimicrobial activity of aqueous extract, andrographolides and arabinogalactan proteins from andrographis paniculata were evaluated. Pdf phytochemical analysis of andrographis paniculata. A potent antibacterial plant qamar uddin ahmed 1, othman abd. Minimum inhibitory concentration values were compared with control and zone of inhibition values. Undetectable antibacterial activity of andrographis paniculata burm wall. Samah 2, and abubakar sule 2 1department of pharmaceutical chemistry, faculty of pharmacy, 2department of biomedical science, faculty of allied health sciences, international islamic university malaysia, kuantan, pahang. Antimicrobial activities of endophytic fungi isolates from medicinal tree melia azedarach.
Phytochemical screening and antimicrobial activity of ethanolic extract of andrographis paniculata v rajalakshmi, dr. The in vitro antimicrobial of activity of ethanol, methanol, acetone, chloroform and petroleum ether extracts ofandrographis neesianaleaf showed in table 1. Investigation of the phytochemicals, antioxidant, and. Antibacterial activity of ethanol extract of andrographis. The aim of the study was to investigate the antifungal activity of different part of extracts of a. Although, its antibacterial property has been shown by some researchers, there are very few studies showing its antioxidant activity and there are no reports of its antifungal activity against dermatophytes. The chloroform extract were found to be highly active against. These are the main pharmacological potential of andrographis paniculata. Andrographis paniculata, a plant originating in india, is a traditional remedy for fever and various infections. Andrographis paniculata kalmegh has been considered as a medicinal shrub and used as a medicinal plant in the remote areas of bangladesh. Andrographis paniculata belongs to the acanthaceae family and is. Antimicrobial activity of andrographis paniculata stem extracts.
Tan yee kuan the increasing of antibiotic resistance bacteria and synthetic drugs has urged the search of new antibacterial and antioxidant agents from medicinal plants. Andrographis paniculata, are chosen to study their antibacterial activity on b. Antibacterial activity of andrographis paniculata in the present study the ethanol extract of the aerial part of andrographis paniculata was prepared and evaluated for antimicrobial activity against eleven bacterial strains by determining minimum inhibitory concentration and zone of inhibition. Introduction and experimental medicinal herbs are widely used with a greater number of people seeking remedies and health approaches free from side effects caused by synthetic. Pdf pharmacological activity of andrographis paniculata. Phytochemical analysis of andrographis paniculata extract and its antimicrobial activity.
Bombax ceiba and andrographis paniculata are selected for the antimicrobial and phytochemical analysis on the basis of medicinal folklore rep orts and literature data. Antimicrobial activity of andrographis paniculata request pdf. Andrographis paniculata are known to produce powerful anti biofilm and antiinflammatory compounds 3. Antimalarial activity of extracts of malaysian medicinal plants. The antimicrobial activity of aqueous leaf extract of a. Inhibition of quorum sensing in bacteria can reduce the risk of pathogenicity in all bacterial infection. Preliminary phytochemical and antimicrobial screening of. Phytochemical analysis of andrographis paniculata and.
Andrographis paniculata, the key facts for therapeutic use. The in vitro antibacterial screening results of crude 95% ethanolic extracted under normal stress showed a. Andrographis paniculata, acanthaceae, antimicrobial activity, skin infections, mic. Antimicrobial bacteria, fungi activity of andrographis. Antiheptotoxicactivity, antimalarial activity, antithrombogenic activity, antiinflammatory activity, antisnakevenom activity, respiratory system benefits, and antifertility activity. An investigation on the antimicrobial activity of andrographis paniculata extracts and andrographolide in vitro author. Andrographis paniculata extract or andrographolide. It is reported has a broad category of pharmacological activity, such as hepatoprotective, gastroprotective. Antimicrobial activity of leaf extract of andrographis paniculata wall degree college dandeli581 325 2. In the present study the ethanol extract of the aerial part of andrographis paniculata was prepared and evaluated for antimicrobial activity against eleven bacterial strains by determining minimum inhibitory concentration and zone of inhibition. Our results confer the utility of this plant extracts in developing a novel broad spectrum antimicrobial agent. Andrographis supplements have not been approved by the fda for medical use.
So, in this study we evaluate the antibacterial, antifungal and. Samah1, muhammad nor omar1, abdulrashid umar2, and bashar bello s. Bioassay guided isolation of antibacterial compounds from. Antifungal activity of andrographis paniculata extracts. Medicinal and pharmacological activities of andrographis. Andrographis paniculata ap is a traditional herbal medicine which is widely used for the treatment of many diseases in asia. This project was carried out to study the antibacterial activity and antioxidant activity of leaf extract of andrographis paniculata. Experimental and clinical pharmacology of andrographis. The plant andrographis paniculata, is an antibacterial agent capable of counteracting the ill effects of pathogenic microbes 5356. Antibacterial activity of chrysanthemum indicum centella. Antimicrobial and antiparasitic effects in traditional systems of medicine a. Andrographis serpyllifolia and their antimicrobial and antioxidant activity sashikiran palithya 1, venkata subbaiah kotakadi 2, josthna pechalaneni 3, varadarajulu naidu challagundla 1, 1 department of biotechnology, dravidian university, kuppam, andhra pradesh, india 2 dstpurse centre, sri venkateswara university, tirupati, andhra. Phytochemical analysis of andrographis paniculata extract and.
People historically used it for the common cold, sinus infections, general inflammation, pain, and detoxification 1, 2. Andrographis neesiana, antimicrobial activity, medicinal plant. Antimicrobial and antiparasitic effects in traditional. Antibacterial and antifungal activity of flowers of.
The antimicrobial activity of the extracts was evaluated using the broth dilution method. Mechanism of inhibition of hiv1 infection in vitro by a purified extract of prunella vulgaris. Most of the drugs used today are acquired from natural sources or semi. Flower of andrographis paniculata, chloroform, methanol, antimicrobial activity. Most studies for hepatic effects have been conducted on either andrographolide or other purportedly active principles.
The results antimicrobial activity are given in the table 1 and 2. The results obtained in the present study indicate that the leaves of andrographis paniculata showed the best antibacterial activity against the. Mukkur 2006 an investigation on the antimicrobial activity of andrographis paniculata extracts and andrographolide in vitro. Recently, various biological activities of ap extract or andrographolide and, such as immunostimulatory activity, antiinflammatory effect, cytokine induction or deduction, a potential cancer therapeutic agent and t cell activation suppression, have been reported. Andrographis paniculata, bioassayguided isolation, antibacterial compounds introduction andrographis paniculata burm.
L cathrine abstract medicines of plant origin have been used to combat human diseases since time immemorial even before the history of their documentation. Minimum inhibitory concentration values were compared with control and zone of. In vitro antimicrobial activity of gel containing the. Andrographis paniculata possess hepatoprotective, antiinflammatory, immunostimulatory, antipyretic, antioxidant, hypotensive, antibacterial activities.
Infectious diseases are one of the significant causes of mortality and morbidity in. Phytochemical extraction and characterization of the leaves. Antimicrobial activity and stability of andrographis. Andrographis paniculata contains steroids, phenols, terpenoids, alkaloids, saponins, flavonoids were the active compounds present in the plant. In vitro antimicrobial activities of endophytic fungi. Andrographis paniculata do possesses some antibacterial activity against staphylococcus aureus. The present research was conducted to discover antimicrobial compounds in methanolic leaf extracts of jatropha curcas and andrographis paniculata and ethanolic leaf extract of psidium guajava and the effectiveness against microbes on flower preservative solution of cut mokara red orchid flowers was evaluated. Introduction plants produce a wide range of bioactive molecules, making them rich source of different types of medicines. Screening for antibacterial activity of andrographis. In vitro antimicrobial activity of gel containing the herbal. An aqueous and two ethanolic extracts of andrographis paniculata, used in traditional chinese, thai and indian medicine and andrographolide, an active principle of andrographis paniculata, were investigated for their antimicrobial activity against nine bacterial species including salmonella typhimurium, escherichia coli, shigella sonnei, staphylococcus aureus. The maximum antimicrobial activity was noted in petroleum ether extracts of stem showed activity. Antimicrobial activity of andrographis paniculata sciencedirect. Adaptive immune responsemodifying and antimicrobial.
95 741 994 446 913 1466 1133 1153 977 949 1141 908 47 892 937 249 454 125 794 179 1375 451 709 1309 1188 1009 38 274 151 882 1 239 587 1041 293 1204